Fraunhofer ATTRACT "3DNanoCell"The Fraunhofer Institute for Silicate Research ISC
Fraunhofer Attract »3DNanoCell« is headed by Prof. Dr. rer. nat. Doris Heinrich and specialized in the development of cell-based 3D assays and 3D scaffolds for tissue engineering. Research is focussed on the analysis of interactions between novel (nano)structured scaffold materials and biological systems. High resolution live cell fluorescence microscopy is combined with state-of-the-art cell function stimulation techniques.
Development of 3D-Scaffolds and Nano Carriers
R&D goal is to adapt innovative materials for bioactive surfaces and 3D scaffolds. To this effect, laser controlled production methods for 3D scaffolds are adapted for use in tissue engineering and regenerative medicine. Also, nanoparticles synthesized for target applications are modified to serve as drug carriers or optimized to direct and control cell functions.
The Vision of "Remote-Controlled Cells"
To modify scaffolds for cell-type specific use, »3DNanoCell« is investigating the cytoskeleton regulation to control and direct cell functions.
The understanding of living cells and their interaction with materials, surfaces and generally any physical or chemical impact from the cell environment will promote novel developments and solutions in medicine, e.g. accelerated tissue regeneration.
Regenerative Medicine and Tissue Engineering
In regenerative medicine, the capability for self-healing of the human body is controlled to optimize the accelerated integration of high-tech scaffold materials with cell tissue in the biological surrounding. In tissue engineering, 3D scaffolds foster the in vitro growth of tissue.
Both areas of modern medicine benefit from custom-designed 3D scaffolds in combination with nanoscale surface structuring and biochemical functionalization to achieve optimal colonization by living cells. 3D scaffolds help to ensure that cells are sufficiently cross-linked in space and supplied with nutrients in all scaffold areas.
Heinrich Group at Leiden University (Biophysics of Cellular Dynamics)